(4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

Base Information

Chemical Name:(4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone
CAS No.:857531-68-1
Molecular Formula:C₃₅H₂₆ClN₃O
Molecular Weight:540.064
Hs Code.:

Synonyms:(4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

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Chemical Property of (4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

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Technology Process of (4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

There total 4 articles about (4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 857531-67-0
6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-nicotinonitrile

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 857531-68-1
(4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

Guidance literature:: 6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-nicotinonitrile; (4-chlorphenyl)magnesium bromide; In tetrahydrofuran; diethyl ether; for 16h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; for 1h; pH=2;

With sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water; pH=8;

Reference yield: 77.0%

: 857531-67-0
6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-nicotinonitrile

: 4-chlorobenzenemagnesium bromide

: 857531-68-1
(4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 857531-68-1
(4-chloro-phenyl)-[6-(3-methyl-1-trityl-1H-pyrazol-4-yl)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 135 °C / Microwave irradiation

2.1: tetrahydrofuran; diethyl ether / 16 h

2.2: 1 h / pH 2

2.3: pH 8

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water;