2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

Base Information

Chemical Name:2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol
CAS No.:1616294-99-5
Molecular Formula:C₂₅H₃₁N₅O₂
Molecular Weight:433.553
Hs Code.:

Synonyms:2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

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Chemical Property of 2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

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Technology Process of 2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

There total 3 articles about 2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1616296-04-8
C₂₄H₂₉N₅O₂

: 1616294-99-5
2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield:

: 1616296-00-4
C₂₂H₂₅N₅O

: 1616294-99-5
2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

2: sodium cyanoborohydride / methanol / 20 °C

With sodium cyanoborohydride; potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1616295-99-8
C₂₂H₂₃N₅O₃

: 1616294-99-5
2-({2-cyclopropyl-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazolin-6-yl}-methyl-amino)-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / ethanol; water / 3 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 120 °C

3: sodium cyanoborohydride / methanol / 20 °C

With iron; sodium cyanoborohydride; potassium carbonate; ammonium chloride; In methanol; ethanol; water; N,N-dimethyl-formamide;