{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

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Chemical Name:{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid
CAS No.:1026796-74-6
Molecular Formula:C₃₉H₄₅N₉O₁₂
Molecular Weight:831.839
Hs Code.:

{[(4-benzyloxycarbonylamino-2-oxo-2<i>H</i>-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-<i>tert</i>-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

Synonyms:{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

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Chemical Property of {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

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Technology Process of {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

There total 12 articles about {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1026938-60-2
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

: 1026796-74-6
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.75h;
DOI:10.1021/jo001650o

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 1026796-74-6
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / pyridine / CH₂Cl₂ / 1.5 h

2: 58 percent / PPh₃; CBr₄ / tetrahydrofuran / 2 h / 20 °C

3: 92 percent / DIPEA / dimethylformamide / 20 °C

4: 72 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

5: 91 percent / Bu₃SnH; Pd(PPh₃)4 / CH₂Cl₂; H₂O / 0.25 h

6: 69 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

7: 88 percent / aq. LiOH / tetrahydrofuran / 0.75 h / 20 °C

With pyridine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001650o

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1026796-74-6
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃ / CHCl₃; acetonitrile

2: EDC / dimethylformamide

3: LiOH; H₂O / tetrahydrofuran

4: 69 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

5: 88 percent / aq. LiOH / tetrahydrofuran / 0.75 h / 20 °C

With lithium hydroxide; water; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo001650o