(+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

Base Information

Chemical Name:(+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester
CAS No.:1421348-76-6
Molecular Formula:C₂₉H₃₅N₃O₃
Molecular Weight:473.615
Hs Code.:

Synonyms:(+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

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Chemical Property of (+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

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Technology Process of (+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

There total 8 articles about (+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421348-75-5
(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1421348-76-6
(+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 612-58-8
3-methylquinoline

: 1421348-76-6
(+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; acetic acid / water / 16 h / 80 °C

2: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 28 h / 20 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 50 °C

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 20 °C

With dihydrogen peroxide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 34970-18-8
3,3-dimethylcyclobutanecarboxylic acid

: 1421348-76-6
(+/-)-3-{4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoylamino}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / dichloromethane / 4 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 2.25 h / -30 °C

2.2: 0.42 h / -30 - -20 °C

2.3: 4.08 h / -40 - 0 °C

3.1: sodium cyanoborohydride; ammonium acetate / methanol / 17 h / 60 °C

4.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 28 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 50 °C

6.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 20 °C

With TurboGrignard; oxalyl dichloride; ammonium acetate; sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;