C₁₄H₁₆O₂

Base Information

• Chemical Name: C₁₄H₁₆O₂
• CAS No.: 1206483-29-5
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.28
• Mol file: 1206483-29-5.mol

Synonyms:C₁₄H₁₆O₂

Chemical Property of C₁₄H₁₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₆O₂

There total 1 articles about C₁₄H₁₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-5-t-butylbenzaldehyde (2725-53-3) + propargyl bromide (106-96-7) → C14H16O2 (1206483-29-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1055/s-0030-1258768

Reference yield:

C14H16O2 (1206483-29-5) → dimethyl 8-(tert-butyl)-3-phenyl-1,9b-dihydrocyclopenta[c]chromene-2,2(4H)-dicarboxylate (1383545-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere

2: piperidine / chloroform / Reflux

3: sodium hydride / dimethyl sulfoxide / 3 h / 0 - 50 °C / Inert atmosphere

4: scandium tris(trifluoromethanesulfonate) / 1,1-dichloroethane / 6 h / 75 °C / Molecular sieve

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; 1,1-dichloroethane; chloroform; dimethyl sulfoxide;

DOI:10.1002/asia.201200104

Reference yield:

C14H16O2 (1206483-29-5) → C25H26O5

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere

2: piperidine / chloroform / Reflux

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; chloroform;

DOI:10.1002/asia.201200104

upstream raw materials:

2-hydroxy-5-t-butylbenzaldehyde

propargyl bromide

Downstream raw materials:

dimethyl 8-(tert-butyl)-3-phenyl-1,9b-dihydrocyclopenta[c]chromene-2,2(4H)-dicarboxylate

dimethyl 2-(5-(tert-butyl)-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate