N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Base Information

Chemical Name:N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide
CAS No.:1361409-70-2
Molecular Formula:C₂₁H₁₆ClFN₄O₂S₂
Molecular Weight:474.967
Hs Code.:

Synonyms:N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

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Chemical Property of N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

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Technology Process of N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

There total 4 articles about N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1283481-91-3
N-(5-(2-bromoacetyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

: 63980-69-8
(2-methoxy-5-chlorophenyl)-2-thiourea

: 1361409-70-2
N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Guidance literature:: In ethanol; for 1.5h; Reflux;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 321532-91-6
N-(5-acetyl-4-methylthiazol-2-yl)-4-fluorobenzamide

: 1361409-70-2
N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid / 48 h / 20 °C

2: ethanol / 1.5 h / Reflux

With pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid; In ethanol;
DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

: 30748-47-1
5-acetyl-4-methylthiazole-2-amine

: 1361409-70-2
N-(2-(5-chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 100 °C

2.1: pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid / 48 h / 20 °C

3.1: ethanol / 1.5 h / Reflux

With pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid; 1,1'-carbonyldiimidazole; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.128