(2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane

Base Information

• Chemical Name: (2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane
• CAS No.: 615585-11-0
• Molecular Formula: C₂₁H₂₆O₄
• Molecular Weight: 342.435
• Mol file: 615585-11-0.mol

Synonyms:(2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane

Chemical Property of (2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane

There total 1 articles about (2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl bromide (100-39-0) + (2R,4R)-4-hydroxymethyl-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane (333956-92-6) → (2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane (615585-11-0)

Guidance literature:

(2R,4R)-4-hydroxymethyl-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane; With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 50 - 80 ℃; for 3h;

DOI:10.1016/S0040-4020(03)00479-4

Reference yield: 86.0%

(2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane (615585-11-0) → (R)-4-(benzyloxy)-2,2-dimethylbutane-1,3-diol (615585-08-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1016/S0040-4020(03)00479-4

Reference yield:

(2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-4-benzyloxymethyl-1,3-dioxane (615585-11-0) → (3R)-4-benzyloxy-2,2-dimethyl-3-hydroxy-1-butanal

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / aq. HCl / tetrahydrofuran / 20 h / 20 °C

2: 72 percent / N-chlorosuccinimide; K₂CO₃; N-tert-butylbenzenesulfenamide / molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; N-chloro-succinimide; N-(phenylthio)-N-(tert-butyl)amine; potassium carbonate; 4 A molecular sieve; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(03)00479-4

upstream raw materials:

benzyl bromide

(2R,4R)-4-hydroxymethyl-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane

Downstream raw materials:

(R)-4-(benzyloxy)-2,2-dimethylbutane-1,3-diol