diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

Base Information

Chemical Name:diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester
CAS No.:205931-17-5
Molecular Formula:C₂₄H₂₉NO₃
Molecular Weight:379.499
Hs Code.:

diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[<i>b</i>]oxepin-6-yl ester

Synonyms:diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

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Chemical Property of diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

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Technology Process of diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

There total 9 articles about diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 205931-01-7
diethyl-carbamic acid 2-allyl-3-(2-methyl-allyloxy)-5-phenethyl-phenyl ester

: 205931-17-5
diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

Guidance literature:: Grubbs catalyst first generation; In dichloromethane;
DOI:10.1021/jo980299s

Reference yield:

: 78916-49-1,21956-55-8,21956-56-9
1-phenyl-2-(3,5-dimethoxyphenyl)ethene

: 205931-17-5
diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / Pd-C

2.1: NaSEt / dimethylformamide

3.1: K₂CO₃ / acetonitrile

4.1: s-BuLi; TMEDA / tetrahydrofuran

4.2: MgBr₂*Et₂O / tetrahydrofuran

4.3: 70 percent / tetrahydrofuran

5.1: BBr₃ / CH₂Cl₂

6.1: K₂CO₃ / dimethylformamide

7.1: 77 percent / [RuCl₂(PhCH=)(PCy₃)2] / CH₂Cl₂

With N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; boron tribromide; potassium carbonate; sodium thioethylate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Catalytic hydrogenation / 2.1: demethylation / 3.1: Acylation / 4.1: Metallation / 4.2: transmetallation / 4.3: Alkylation / 5.1: demethylation / 6.1: Etherification / 7.1: Cyclization;
DOI:10.1021/jo980299s

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 205931-17-5
diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran

2.1: H₂ / Pd-C

3.1: NaSEt / dimethylformamide

4.1: K₂CO₃ / acetonitrile

5.1: s-BuLi; TMEDA / tetrahydrofuran

5.2: MgBr₂*Et₂O / tetrahydrofuran

5.3: 70 percent / tetrahydrofuran

6.1: BBr₃ / CH₂Cl₂

7.1: K₂CO₃ / dimethylformamide

8.1: 77 percent / [RuCl₂(PhCH=)(PCy₃)2] / CH₂Cl₂

With N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; boron tribromide; potassium carbonate; sodium thioethylate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Wittig reaction / 2.1: Catalytic hydrogenation / 3.1: demethylation / 4.1: Acylation / 5.1: Metallation / 5.2: transmetallation / 5.3: Alkylation / 6.1: demethylation / 7.1: Etherification / 8.1: Cyclization;
DOI:10.1021/jo980299s