2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide

Base Information

• Chemical Name: 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide
• CAS No.: 313685-55-1
• Molecular Formula: C₁₇H₁₅Cl₂FN₂O₄S
• Molecular Weight: 433.288
• Mol file: 313685-55-1.mol

Synonyms:2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide

Chemical Property of 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide

There total 5 articles about 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

meta-fluoroaniline (372-19-0) + 2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride → 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide (313685-55-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01270

Reference yield:

meta-fluoroaniline (372-19-0) + 2,4-dichloro-5-(morpholinosulfonyl)benzoic acid (292644-05-4) → 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide (313685-55-1)

Guidance literature:

2,4-dichloro-5-(morpholinosulfonyl)benzoic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

meta-fluoroaniline; With pyridine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl)benzamide (313685-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 16 h / 140 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / Inert atmosphere

2.2: 12 h / Inert atmosphere

3.1: phosgene; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With pyridine; phosgene; chlorosulfonic acid; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/acs.jmedchem.6b01270

upstream raw materials:

2,4 dichlorobenzoic acid

2,4-dichloro-5-(chlorosulfonyl)benzoic acid

2,4-dichloro-5-(morpholinosulfonyl)benzoic acid

meta-fluoroaniline