Technology Process of N-cyclopropyl-N-ethyl-5-(2,4-dimethoxybenzyl)-6-oxo-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinoline-2-carboxamide
There total 8 articles about N-cyclopropyl-N-ethyl-5-(2,4-dimethoxybenzyl)-6-oxo-6,7,8,9,10,11-hexahydro-5H-cyclohepta[c]quinoline-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate;
In
N,N-dimethyl acetamide;
at 130 ℃;
for 4h;
Inert atmosphere;
DOI:10.1016/j.bmc.2014.05.022
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / water; acetonitrile / 20 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 °C
2.2: 2 h / 60 °C
3.1: palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate / N,N-dimethyl acetamide / 4 h / 130 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; dihydrogen peroxide; palladium diacetate; caesium carbonate; N,N-dimethyl-formamide; tricyclohexylphosphine tetrafluoroborate;
In
dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;
3.1: |Heck Reaction;
DOI:10.1016/j.bmc.2014.05.022
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphorus tribromide / chloroform / 4 h / 0 - 20 °C / Reflux
2.1: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / water; acetonitrile / 20 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 °C
3.2: 2 h / 60 °C
4.1: palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate / N,N-dimethyl acetamide / 4 h / 130 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; dihydrogen peroxide; palladium diacetate; phosphorus tribromide; caesium carbonate; N,N-dimethyl-formamide; tricyclohexylphosphine tetrafluoroborate;
In
dichloromethane; chloroform; N,N-dimethyl acetamide; water; acetonitrile;
4.1: |Heck Reaction;
DOI:10.1016/j.bmc.2014.05.022
