(5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

Base Information

Chemical Name:(5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol
CAS No.:454474-79-4
Molecular Formula:C₂₂H₃₈O₉
Molecular Weight:446.538
Hs Code.:

Synonyms:(5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

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Chemical Property of (5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

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Technology Process of (5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

There total 4 articles about (5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 220776-83-0
tert-Butyl-((R)-5-{(4S,5R)-5-[(1S,2S)-2-(4-methoxy-benzyloxy)-1-methoxymethoxy-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methoxymethoxy-pentyloxy)-diphenyl-silane

: 220776-84-1
(2S,3R,4S,5R,6R)-10-tert-butyldiphenylsilyloxy-3,6-bis(methoxymethoxy)-2-p-methoxybenzyloxy-4,5-decanediol

: 454474-79-4
(5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

Guidance literature:: With acetic acid; at 20 ℃; for 24h;
DOI:10.1021/jo020211h

Reference yield:

: 220776-81-8
(5S,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

: 454474-79-4
(5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

Guidance literature:: Multi-step reaction with 4 steps

1.1: MnO₂ / CH₂Cl₂ / 12 h / 20 °C

1.2: 72 percent / NaBH₄; CeCl₃*7H₂O / methanol / 3 h / 0 °C

2.1: 90 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 96 h / 20 °C

3.1: 95 percent / H₂ / Rh/Al₂O₃ / ethyl acetate / 24 h / 20 °C

4.1: 23 percent / aq. AcOH / 24 h / 20 °C

With manganese(IV) oxide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; Rh/Al₂O₃; In dichloromethane; ethyl acetate;
DOI:10.1021/jo020211h

Reference yield:

: 454474-78-3
tert-Butyl-((R)-5-{(4S,5R)-5-[(1S,2S)-2-(4-methoxy-benzyloxy)-1-methoxymethoxy-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methoxymethoxy-pent-3-ynyloxy)-diphenyl-silane

: 454474-79-4
(5R,6R,7S,8R,9S)-5,8-bis-bis(methoxymethoxy)-9-p-methoxybenzyloxy-1,6,7-decanetriol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / Rh/Al₂O₃ / ethyl acetate / 24 h / 20 °C

2: 23 percent / aq. AcOH / 24 h / 20 °C

With hydrogen; acetic acid; Rh/Al₂O₃; In ethyl acetate;
DOI:10.1021/jo020211h