(5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

Base Information

• Chemical Name: (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol
• CAS No.: 220776-82-9
• Molecular Formula: C₃₇H₄₈O₇Si
• Molecular Weight: 632.869

Synonyms:(5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

Chemical Property of (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

There total 2 articles about (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(5S,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol (220776-81-8) → (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol (220776-82-9)

Guidance literature:

(5S,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol; With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 12h;

With sodium tetrahydroborate; cerium(III) chloride; In methanol; at 0 ℃; for 3h; Further stages.;

DOI:10.1021/jo020211h

Reference yield: 67.0%

4-(tert-butyldiphenylsilyloxy)-1-butyne (88158-68-3) + 2,3-O-isopropylidene-5-O-p-methoxybenzyl-L-rhamnofuranose (454474-75-0) → (5S,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol (220776-81-8) + (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol (220776-82-9)

Guidance literature:

In diethyl ether; hexane; -78 deg C to RT;

DOI:10.1016/S0040-4039(98)02440-X

Reference yield: 90.0%

chloromethyl methyl ether (107-30-2) + (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol (220776-82-9) → tert-Butyl-((R)-5-{(4S,5R)-5-[(1S,2S)-2-(4-methoxy-benzyloxy)-1-methoxymethoxy-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methoxymethoxy-pent-3-ynyloxy)-diphenyl-silane (454474-78-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 96h;

DOI:10.1021/jo020211h

upstream raw materials:

4-(tert-butyldiphenylsilyloxy)-1-butyne

2,3-O-isopropylidene-5-O-p-methoxybenzyl-L-rhamnofuranose

(5S,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

Downstream raw materials:

tert-Butyl-((R)-5-{(4S,5R)-5-[(1S,2S)-2-(4-methoxy-benzyloxy)-1-methoxymethoxy-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methoxymethoxy-pent-3-ynyloxy)-diphenyl-silane

(2S,3R,6R)-(Z)-10-tert-butyldiphenylsilyloxy-3,6-bis(methoxymethoxy)-4-decene-2-ol

(2'R,3R,4R,5S)-3-(6'-tert-butyldiphenylsilyloxy-2'-(methoxymethoxy)hexyl)-5-methyltetrahydrofuran-2-one

(2S,3R,6R)-(Z)-10-tert-butyldiphenylsilyloxy-3,6-bis(methoxymethoxy)-2-p-methoxybenzyloxy-4-decene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 220776-82-9 (5R,6S,7R,8S,9S)-6,7-isopropylidenedioxy-9-p-methoxybenzyloxy-3-decyne-5,8-diol

Send

Send

Metric Ton KG G Pound L ML

Send

Send