(8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride

Base Information

• Chemical Name: (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride
• CAS No.: 1211399-89-1
• Molecular Formula: C₁₅H₁₇N₃O₂*ClH
• Molecular Weight: 307.78
• Mol file: 1211399-89-1.mol

Synonyms:(8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride

Chemical Property of (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride

There total 5 articles about (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate (1211399-88-0) → (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride (1211399-89-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 2h; optical yield given as %de;

DOI:10.1016/j.bmcl.2011.06.023

Reference yield:

C4H6O6*C9H11N (220241-67-8) → (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride (1211399-89-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / diethyl ether; water

2: sodium hydrogencarbonate / dichloromethane; water

3: dichloromethane / 1 h

4: hydrogenchloride / 1,4-dioxane; water / 2 h

With hydrogenchloride; sodium hydrogencarbonate; sodium hydroxide; In 1,4-dioxane; diethyl ether; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.06.023

Reference yield:

(1S,2R)-tranylcypromine (3721-28-6) → (8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride (1211399-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane; water

2: dichloromethane / 1 h

3: hydrogenchloride / 1,4-dioxane; water / 2 h

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.06.023

upstream raw materials:

1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate

C₄H₆O₆*C₉H₁₁N

(1S,2R)-tranylcypromine

trans-2-phenylcyclopropylamine

Downstream raw materials:

(8aS)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

(8aS)-N-(2,3-dichlorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

(8aS)-7-[(1-methylcyclopropyl)carbonyl]-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione

(8aS)-N-(4-chloro-2-cyclopropylpyridin-3-yl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide