1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate
• CAS No.: 1211399-88-0
• Molecular Formula: C₂₁H₂₉N₃O₅
• Molecular Weight: 403.478
• Mol file: 1211399-88-0.mol

Synonyms:1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate

Chemical Property of 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate

There total 4 articles about 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O1-tert-butyl O3-methyl (3S)-piperazine-1,3-dicarboxylate (314741-39-4) + trans-2-phenylcyclopropyl isocyanate → 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate (1211399-88-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

Reference yield:

C4H6O6*C9H11N (220241-67-8) → 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate (1211399-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / diethyl ether; water

2: sodium hydrogencarbonate / dichloromethane; water

3: dichloromethane / 1 h

With sodium hydrogencarbonate; sodium hydroxide; In diethyl ether; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.06.023

Reference yield:

(1S,2R)-tranylcypromine (3721-28-6) → 1-tert-butyl 3-methyl (3S)-4-({[(1S,2R)-2-phenylcyclopropyl]amino}carbonyl)-1,3-piperazinedicarboxylate (1211399-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; water

2: dichloromethane / 1 h

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1016/j.bmcl.2011.06.023

upstream raw materials:

O₁-tert-butyl O₃-methyl (3S)-piperazine-1,3-dicarboxylate

C₄H₆O₆*C₉H₁₁N

(1S,2R)-tranylcypromine

trans-2-phenylcyclopropylamine

Downstream raw materials:

(8aS)-2-[(1S,2R)-2-phenylcyclopropyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione hydrochloride

C₂₀H₂₅N₃O₄

(8aS)-N-biphenyl-2-yl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide

C₂₁H₂₇N₃O₄