ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate

Base Information

• Chemical Name: ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate
• CAS No.: 1436428-61-3
• Molecular Formula: C₂₂H₂₅N₇O₄
• Molecular Weight: 451.485
• Mol file: 1436428-61-3.mol

Synonyms:ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate

Chemical Property of ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate

There total 7 articles about ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

Ethyl 4-bromobutyrate (2969-81-5) + 4-[2-(7-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)-ethyl]-phenol (139180-30-6) → ethyl 4-(4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)-phenoxy)butanoate (1436428-60-2) + ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate (1436428-61-3) + ethyl 4-((5-((4-(4-ethoxy-4-oxobutoxy)phenethyl)amino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate (1436428-62-4)

Guidance literature:

With potassium carbonate; In acetone; at 20 - 50 ℃; for 48h;

DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

N-(furan-2-ylcarbonyl)carbonohydrazonic diamide (6053-32-3) → ethyl 4-(4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)-phenoxy)butanoate (1436428-60-2) + ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate (1436428-61-3) + ethyl 4-((5-((4-(4-ethoxy-4-oxobutoxy)phenethyl)amino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate (1436428-62-4)

Guidance literature:

Multi-step reaction with 5 steps

1: water / 1 h / 140 °C / 4500.45 Torr / Microwave irradiation

2: 1 h / 170 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / -5 - 20 °C

4: acetonitrile / 20 °C

5: potassium carbonate / acetone / 48 h / 20 - 50 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

3-Amino-5-(furan-2-yl)-1H-1,2,4-triazole (3663-61-4) → ethyl 4-(4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)-phenoxy)butanoate (1436428-60-2) + ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate (1436428-61-3) + ethyl 4-((5-((4-(4-ethoxy-4-oxobutoxy)phenethyl)amino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate (1436428-62-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1 h / 170 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / -5 - 20 °C

3: acetonitrile / 20 °C

4: potassium carbonate / acetone / 48 h / 20 - 50 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2013.03.070

upstream raw materials:

N-(furan-2-ylcarbonyl)carbonohydrazonic diamide

3-Amino-5-(furan-2-yl)-1H-1,2,4-triazole

LUF₅₄₄₃

7-amino-2-(2-furyl)-5-methylsulfonyl<1,2,4>triazolo<1,5-a><1,3,5>triazine