3663-61-4

Basic information

• Product Name: 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI)
• Synonyms: 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI);3-(2-furyl)-1H-1,2,4-triazol-5-amine(SALTDATA: FREE);3-(2-furyl)-1H-1,2,4-triazol-5-amine;[5-(2-furyl)-1H-1,2,4-triazol-3-yl]amine;3-(furan-2-yl)-1H-1,2,4-triazol-5-amine;5-(2-furyl)-1H-1,2,4-triazol-3-amine;5-furan-2-yl-1H-1,2,4-triazol-3-amine;5-(furan-2-yl)-2H-1,2,4-triazol-3-amine
• CAS NO: 3663-61-4
• Molecular Formula: C₆H₆N₄O
• Molecular Weight: 150.14
• Product Categories: AMINEPRIMARY
• Mol File: 3663-61-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 211-212 °C
• Boiling Point: 413.849°C at 760 mmHg
• Flash Point: 204.089°C
• Appearance: /
• Density: 1.436g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.78±0.40(Predicted)
• CAS DataBase Reference: 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI)(3663-61-4)
• EPA Substance Registry System: 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI)(3663-61-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 3663-61-4(Hazardous Substances Data)

Usage

General Description

1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI) is a chemical compound with the molecular formula C5H6N4O. It is a triazolamine derivative with a furanyl substituent attached to its 5-position. 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI) has potential pharmaceutical and agricultural applications due to its unique molecular structure and reactivity. It is used in the synthesis of various pharmaceutical compounds and is also studied for its potential use as a plant growth regulator. Additionally, its furanyl group makes it interesting for its potential biological activity and interactions with various targets in living organisms. Overall, 1H-1,2,4-Triazol-3-amine,5-(2-furanyl)-(9CI) is a versatile chemical with a wide range of potential applications in both the pharmaceutical and agricultural industries.

InChI:InChI=1/C6H6N4O/c7-6-8-5(9-10-6)4-2-1-3-11-4/h1-3H,(H3,7,8,9,10)

Upstream product

• 3326-71-4 2-furoic acid hydrazide 
• 17356-08-0 thiourea 
• 611-13-2 2-furoic acid methyl ester 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 6053-32-3 N-(furan-2-ylcarbonyl)carbonohydrazonic diamide 
• 23159-52-6 5-furan-2-yl-[1,2,4]oxadiazol-3-ylamine 
• 1257878-64-0 3-chloro-5-(2-furanyl)-1,2,4-oxadiazole 
• 556-61-6 methyl thioisocyanate 
• 617-90-3 2-furancarbonitrile 
• 10308-82-4 aminoguanidine nitrate 
• 18708-18-4 furfural tosylhydrazone 
• 420-04-2 CYANAMID 
• 98-01-1 furfural 
• 527-69-5 2-furancarbonyl chloride 

Downstream Products

• 139181-27-4 LUF₅₄₄₃ 
• 146351-92-0 5-amino-2-(2-furyl)-7-methylsulfanyl<1,2,4>triazolo<1,5-a><1,3,5>triazine 
• 139179-53-6 7-amino-2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazine 
• 139181-28-5 7-amino-2-(2-furyl)-5-methylsulfonyl<1,2,4>triazolo<1,5-a><1,3,5>triazine 
• 1436428-24-8 N⁵-(4-bromophenethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine 
• 139179-64-9 2-(furan-2-yl)-5-phenethoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine 
• 139180-30-6 4-[2-(7-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)-ethyl]-phenol 
• 1436428-60-2 ethyl 4-(4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)-phenoxy)butanoate 
• 1436428-61-3 ethyl 4-((2-(furan-2-yl)-5-((4-hydroxyphenethyl)amino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate 
• 1436428-62-4 ethyl 4-((5-((4-(4-ethoxy-4-oxobutoxy)phenethyl)amino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)amino)butanoate 
• 1436428-63-5 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate 
• 1436428-64-6 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl butyrate 
• 1436428-65-7 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl decanoate 
• 260273-22-1 C₉H₈N₆O₂S 

Relevant articles and documents

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

TRIAZOLOTRIAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS

The present invention provides triazolotriazine derivatives of formula (1) as A2A receptor antagonists. Compounds of formula (1) and pharmaceutical compositions including the compounds can be used for the treatment of disorders related to A2A receptor hyp

A green one-pot synthesis of 3(5)-substituted 1,2,4-triazol-5(3)-amines as potential antimicrobial agents

Abstract: An efficient procedure was proposed for the synthesis of 3(5)-substituted 1,2,4-triazol-5(3)-amines via a one-pot reaction of thiourea, dimethyl sulfate and various hydrazides. 1,2,4-Triazole derivatives were prepared in aqueous media under mild conditions while adhering to some principles of green chemistry. The products were easily isolated in 83–95% yields without any need for further purification. Inhibitory activities of all synthetic compounds were assessed against a variety of Gram-positive and Gram-negative pathogenic bacteria as well as some fungal pathogens. The best antibacterial effects were observed with 3(5)-phenyl-1H-1,2,4-triazol-5(3)-amine according to its MIC values (4–8?μg?mL?1). All compounds were successful in blocking the growth of fungi. Acceptable antioxidant properties were observed only with 3(5)-(4-nitrophenyl)-1H-1,2,4-triazol-5(3)-amine. Graphic abstract: 3(5)-Substituted 1,2,4-triazol-5(3)-amines were efficiently prepared via a one-pot reaction of thiourea, dimethyl sulfate and various hydrazides in water as the solvent. Inhibitory activity of all synthesized derivatives was proved according to their MIC, MBC and MFC values. It is found that they are potential antifungal agents.[Figure not available: see fulltext.].