Technology Process of 5-cyclopropyl-2-(4-chlorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid
There total 13 articles about 5-cyclopropyl-2-(4-chlorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; potassium hydroxide;
In
ethanol;
for 1h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
With
water; potassium hydroxide;
In
ethanol;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: zinc(II) chloride / ethanol; tert-butyl methyl ether / 2 h / 75 - 95 °C / Inert atmosphere
2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C
3.1: nitric acid / chloroform / 2.5 h / 0 °C / Cooling with ice
4.1: boron trichloride / dichloromethane / 0.33 h / Cooling with ice; Inert atmosphere
4.2: Cooling with ice
5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
6.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 20 h / Inert atmosphere; Reflux
7.1: hydrogen; [({2-[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]ethyl}oxy)methyl]boronic acid / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C / 3000.3 Torr
8.1: triethylamine / dichloromethane / 2 h / -15 - 20 °C
9.1: potassium hydroxide; water / ethanol / 1 h / Reflux; Inert atmosphere
With
dmap; potassium fluoride; [({2-[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]ethyl}oxy)methyl]boronic acid; water; hydrogen; nitric acid; boron trichloride; caesium carbonate; triethylamine; sodium bromide; potassium hydroxide; zinc(II) chloride;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; tert-butyl methyl ether; chloroform; water; ethyl acetate; toluene;
