Technology Process of ethyl 2-(4-chlorophenyl)-5-hydroxybenzofuran-3-carboxylate
There total 3 articles about ethyl 2-(4-chlorophenyl)-5-hydroxybenzofuran-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
zinc(II) chloride;
In
ethanol; tert-butyl methyl ether;
at 75 - 95 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; magnesium chloride / acetonitrile / 3 h / Cooling with ice
1.2: 20 °C
2.1: zinc(II) chloride / ethanol; tert-butyl methyl ether / 2.5 h / 75 - 155 °C / Inert atmosphere
With
triethylamine; magnesium chloride; zinc(II) chloride;
In
ethanol; tert-butyl methyl ether; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / Reflux
2.1: triethylamine; magnesium chloride / acetonitrile / 3 h / Cooling with ice
2.2: 20 °C
3.1: zinc(II) chloride / ethanol; tert-butyl methyl ether / 2.5 h / 75 - 155 °C / Inert atmosphere
With
oxalyl dichloride; triethylamine; magnesium chloride; zinc(II) chloride;
In
ethanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile;
