tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

Base Information

Chemical Name:tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate
CAS No.:548756-56-5
Molecular Formula:C₁₅H₂₀O₅
Molecular Weight:280.321
Hs Code.:

Synonyms:tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

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Chemical Property of tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

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Technology Process of tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

There total 5 articles about tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 548756-56-5
tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In chloroform-d1; for 168h;
DOI:10.1055/s-2003-37655

Reference yield:

: 548756-58-7
tert-butyl 3-(5-bromo-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate

: 548756-56-5
tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diazabicyclo[2.2.2]octane / CDCl₃

2: 1,4-diazabicyclo[2.2.2]octane / CHCl₃ / 168 h

With 1,4-diaza-bicyclo[2.2.2]octane; In chloroform-d1; chloroform; 1: retro-Baylis-Hillman reaction / 2: Baylis-Hillman reaction;
DOI:10.1039/b300360d

Reference yield:

: 548756-57-6
tert-butyl 3-(3-ethoxy-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate

: 548756-56-5
tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diazabicyclo[2.2.2]octane / CDCl₃

2: 1,4-diazabicyclo[2.2.2]octane / CHCl₃ / 168 h

With 1,4-diaza-bicyclo[2.2.2]octane; In chloroform-d1; chloroform; 1: retro-Baylis-Hillman reaction / 2: Baylis-Hillman reaction;
DOI:10.1039/b300360d