N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Base Information

Chemical Name:N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine
CAS No.:863215-99-0
Molecular Formula:C₂₁H₁₅ClFN₅O₂
Molecular Weight:423.834
Hs Code.:

N<SUP>4</SUP>-(3-chloro-4-fluorophenyl)-N<SUP>6</SUP>-(2-nitrobenzyl)quinazoline-4,6-diamine

Synonyms:N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Suppliers and Price of N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

There total 5 articles about N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 184356-51-2
4-(3'-chloro-4'-fluoroanilino)-6-aminoquinazoline

: 863215-99-0
N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Guidance literature:: With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In Isopropyl acetate; for 2h;
DOI:10.1016/j.bmcl.2020.127472

Reference yield:

: (E)-N'-(2-cyano-4-nitrophenyl)-N,N-dimethylimidoformamide

: 863215-99-0
N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 7 h / 120 °C

2: iron; ammonium chloride / isopropyl alcohol; water / Heating

3: sodium tris(acetoxy)borohydride; trifluoroacetic acid / Isopropyl acetate / 2 h

With sodium tris(acetoxy)borohydride; iron; ammonium chloride; acetic acid; trifluoroacetic acid; In Isopropyl acetate; water; isopropyl alcohol;
DOI:10.1016/j.bmcl.2020.127472

Reference yield:

: 184356-50-1
4-(3'-chloro-4'-fluoroanilino)-6-nitroquinazoline

: 863215-99-0
N⁴-(3-chloro-4-fluorophenyl)-N⁶-(2-nitrobenzyl)quinazoline-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / isopropyl alcohol; water / Heating

2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / Isopropyl acetate / 2 h

With sodium tris(acetoxy)borohydride; iron; ammonium chloride; trifluoroacetic acid; In Isopropyl acetate; water; isopropyl alcohol;
DOI:10.1016/j.bmcl.2020.127472