6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline

Base Information

Chemical Name:6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline
CAS No.:184356-51-2
Molecular Formula:C14H10ClFN4
Molecular Weight:288.712
Hs Code.:
Mol file:184356-51-2.mol

Synonyms:6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline

Suppliers and Price of 6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-AMINO-4-(3-CHLORO-4-FLUOROANILINO)QUINAZOLINE 95.00%
5MG
$ 498.47

Total 8 raw suppliers

Chemical Property of 6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline

Chemical Property:

PSA：63.83000
LogP:4.40230

Purity/Quality:

99% ^*data from raw suppliers

6-AMINO-4-(3-CHLORO-4-FLUOROANILINO)QUINAZOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline

There total 17 articles about 6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 184356-50-1
4-(3'-chloro-4'-fluoroanilino)-6-nitroquinazoline

: 184356-51-2
4-(3'-chloro-4'-fluoroanilino)-6-aminoquinazoline

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; methanol; for 3.5h; under 2585.74 Torr;
DOI:10.1021/jm9806603

Reference yield: 15.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 6943-17-5
6-nitroquinazolone

: 184356-51-2
4-(3'-chloro-4'-fluoroanilino)-6-aminoquinazoline

Guidance literature:: 6-nitroquinazolone; With phosphorus pentachloride; phosphorus trichloride; at 160 ℃; for 6h;

3-chloro-4-fluorophenylamine; In acetonitrile; at 80 ℃; for 2h;

With hydrogen; In methanol; N,N-dimethyl-formamide; at 40 ℃; for 4h; under 760.051 Torr;

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 184356-51-2
4-(3'-chloro-4'-fluoroanilino)-6-aminoquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 96.9 percent / 1.5 h / 100 °C

2: 77.3 percent / AcOH / 1 h / Heating

3: 30.9 percent / iron; AcOH / ethanol / 3 h / Heating

With iron; acetic acid; In ethanol;
DOI:10.1016/j.ejmech.2004.03.010