4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

Base Information

Chemical Name:4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride
CAS No.:1415475-32-9
Molecular Formula:C₁₇H₁₇F₂N₃O₂S*ClH
Molecular Weight:401.865
Hs Code.:

Synonyms:4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

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Chemical Property of 4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

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Technology Process of 4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

There total 6 articles about 4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415475-29-4
tert-butyl 4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1415475-32-9
4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

: 1415475-29-4
tert-butyl 4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1415475-26-1
4-{4-[5-(2,6-difluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

: 1415475-32-9
4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

Guidance literature:: tert-butyl 4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 5h;

4-{4-[5-(2,6-difluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride;

Reference yield:

: 1313010-11-5
tert-butyl 4-{4-[(Z/E)-(hydroxyimino)methyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1415475-32-9
4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide; water; potassium hydrogencarbonate / ethyl acetate / 4 h / 60 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 0 - 20 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 5 h / 0 - 20 °C

With hydrogenchloride; N-chloro-succinimide; water; potassium hydrogencarbonate; In 1,4-dioxane; dichloromethane; ethyl acetate;