1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

Base Information

Chemical Name:1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone
CAS No.:1427659-68-4
Molecular Formula:C₂₇H₂₅F₆N₅O₃S
Molecular Weight:613.584
Hs Code.:

1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

Synonyms:1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

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Chemical Property of 1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

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Technology Process of 1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

There total 5 articles about 1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415475-31-8
2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

: 106-95-6
allyl bromide

: 1427659-68-4
1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: With potassium carbonate; In acetone; for 5h; Reflux;

Reference yield:

: 1415475-32-9
4-{4-[5-(2,6-difluoro-3-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride

: 1427659-68-4
1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: potassium carbonate / acetone / 5 h / Reflux

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetone;

Reference yield:

: 1313010-11-5
tert-butyl 4-{4-[(Z/E)-(hydroxyimino)methyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1427659-68-4
1-[4-(4-{5-[3-(allyloxy)-2,6-difluorophenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / ethyl acetate / 0.5 h / Reflux

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 5 h / 0 - 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: potassium carbonate / acetone / 5 h / Reflux

With hydrogenchloride; N-chloro-succinimide; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; ethyl acetate; acetone;