2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

Base Information

Chemical Name:2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide
CAS No.:847934-56-9
Molecular Formula:C₅₈H₈₀N₄O₁₂P₂
Molecular Weight:1087.24
Hs Code.:

2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

Synonyms:2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

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Chemical Property of 2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

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Technology Process of 2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

There total 5 articles about 2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 847934-55-8
N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

: 847934-56-9
2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 45 ℃; for 24h;
DOI:10.1021/jm0492709

Reference yield:

: 401810-36-4
(2S)-2-amino-N¹-[(2S)-2-(naphthylmethyl)-4-pentenyl]butanediamide

: 847934-56-9
2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 38 percent / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

2: trifluoroacetic acid; anisole / 20 °C

3: 30 mg / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

4: 28 percent / Ru{CH[(2,4,6-Me₃C₆H₂)(CH₂)N]2}(=CHPh)(PCy₃)Cl₂ / CH₂Cl₂ / 24 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methoxybenzene; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0492709

Reference yield:

: 690254-42-3
(2S)-2-(tert-butyloxycarbonyl)amino-3-(4-diethylphosphono)phenylpropionic acid

: 847934-56-9
2-[(1S,5S,9R,13S)-3,12,15-triaza-13-(4-bisethoxyphosphono)phenylmethyl-9-[4-bis(tert-butoxy)phosphonomethyl]phenyl-13-methyl-5-naphthylmethyl-2,11,14-trioxocyclopentadec-7-enyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 38 percent / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

2: trifluoroacetic acid; anisole / 20 °C

3: 30 mg / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

4: 28 percent / Ru{CH[(2,4,6-Me₃C₆H₂)(CH₂)N]2}(=CHPh)(PCy₃)Cl₂ / CH₂Cl₂ / 24 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methoxybenzene; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0492709