N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

Base Information

Chemical Name:N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide
CAS No.:847934-55-8
Molecular Formula:C₆₀H₈₄N₄O₁₂P₂
Molecular Weight:1115.29
Hs Code.:

N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

Synonyms:N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

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Chemical Property of N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

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Technology Process of N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

There total 4 articles about N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 495404-40-5
(2S,3S)-3-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)-2-{[(tert-butyl)oxycarbonyl]methyl}pent-4-enoic acid

: (4-{(S)-2-Amino-2-[(S)-2-carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-propyl}-phenyl)-phosphonic acid diethyl ester

: 847934-55-8
N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0492709

Reference yield:

: 401810-36-4
(2S)-2-amino-N¹-[(2S)-2-(naphthylmethyl)-4-pentenyl]butanediamide

: 847934-55-8
N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

2: trifluoroacetic acid; anisole / 20 °C

3: 30 mg / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

With methoxybenzene; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm0492709

Reference yield:

: 690254-42-3
(2S)-2-(tert-butyloxycarbonyl)amino-3-(4-diethylphosphono)phenylpropionic acid

: 847934-55-8
N-{(1S)-2-(4-bisethoxyphosphono)phenyl-1-methyl-1-[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]ethyl}-(2S,3R)-2-(tert-butoxycarbonylmethyl)-3-{4-[bis(tert-butoxy)phosphonomethyl]phenyl}pent-4-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

2: trifluoroacetic acid; anisole / 20 °C

3: 30 mg / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

With methoxybenzene; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm0492709