(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

Base Information

• Chemical Name: (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one
• CAS No.: 110705-96-9
• Molecular Formula: C₂₈H₂₇ClF₂O₄
• Molecular Weight: 500.97

Synonyms:(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

Chemical Property of (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

There total 12 articles about (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-one (110705-91-4) → (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one (110705-96-9)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jm00114a004

Reference yield:

4-fluoro-3-methylbonzoyl chloride (455-84-5) → (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one (110705-96-9)

Guidance literature:

Multi-step reaction with 8 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

6: glacial acetic acid / tetrahydrofuran / 72 h / Heating

7: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

8: 81 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; aluminium trichloride; Celite; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide;

DOI:10.1021/jm00114a004

Reference yield:

2-chloro-p-cresol (6640-27-3) → (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one (110705-96-9)

Guidance literature:

Multi-step reaction with 8 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

6: glacial acetic acid / tetrahydrofuran / 72 h / Heating

7: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

8: 81 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; aluminium trichloride; Celite; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide;

DOI:10.1021/jm00114a004

upstream raw materials:

(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-one

4-fluoro-3-methylbonzoyl chloride

2-chloro-p-cresol

[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-methanol

Downstream raw materials:

Sodium; (3R,5S)-6-{2-[bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxy}-3,5-dihydroxy-hexanoate

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