1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
• CAS No.: 73627-27-7
• Molecular Formula: C₁₆H₂₀N₂O₃
• Molecular Weight: 288.346
• DSSTox Substance ID: DTXSID30377898
• Mol file: 73627-27-7.mol

Synonyms:73627-27-7;1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine;1-(3,4,5-Trimethoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine;F1386-0126;SCHEMBL11495120;DTXSID30377898;LCMFCXIQZPMJCR-UHFFFAOYSA-N;1-(3,4,5-trimethoxyphenyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine;AKOS005206623;CS-0302189;EN300-237652;1,2,3,4-TETRAHYDRO-1-(3,4,5-TRIMETHOXYPHENYL)PYRROLO(1,2-a)PYRAZINE

Chemical Property of 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 288.14739250
• Heavy Atom Count: 21
• Complexity: 328

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C2C3=CC=CN3CCN2

Technology Process of 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

There total 2 articles about 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(2-aminoethyl)pyrrole (29709-35-1) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-27-7)

Guidance literature:

In acetic acid; for 48h; Ambient temperature;

DOI:10.1055/s-1981-29499

Reference yield:

N-[2-(1H-pyrrol-1-yl)ethyl]acetamide (73627-16-4) → 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / KOH aq. / 2 h / Heating

2: 63 percent / acetic acid / 48 h / Ambient temperature

With potassium hydroxide; In acetic acid;

DOI:10.1055/s-1981-29499

upstream raw materials:

1-(2-aminoethyl)pyrrole

3,4,5-trimethoxy-benzaldehyde

N-[2-(1H-pyrrol-1-yl)ethyl]acetamide