methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate

Base Information

• Chemical Name: methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate
• CAS No.: 1354377-55-1
• Molecular Formula: C₁₇H₂₂N₄O₃S
• Molecular Weight: 362.453
• Mol file: 1354377-55-1.mol

Synonyms:methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate

Chemical Property of methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate

There total 2 articles about methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenyl isothiocyanate (103-72-0) + N-butylamine (109-73-9,85404-21-3) + C8H12N2O4 → methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate (1354377-55-1)

Guidance literature:

N-butylamine; C₈H₁₂N₂O₄; In dichloromethane; at 20 ℃;

phenyl isothiocyanate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2014.07.038

Reference yield: 81.0%

methyl 3-[[(methoxycarbonyl)imino]amino]but-2-enoate (63160-33-8) + phenyl isothiocyanate (103-72-0) + N-butylamine (109-73-9,85404-21-3) → methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate (1354377-55-1)

Guidance literature:

methyl 3-[[(methoxycarbonyl)imino]amino]but-2-enoate; N-butylamine; In chloroform; at 20 ℃;

phenyl isothiocyanate; at 20 ℃; regioselective reaction;

DOI:10.1021/jo2021949

Reference yield: 97.0%

methyl 2-[1-(3-butyl-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl)-ethylidene]hydrazinecarboxylate (1354377-55-1) → 1-butyl-5-(1-hydroxyethylidene)-3-phenyl-2-thioxoimidazolidin-4-one (1354378-09-8)

Guidance literature:

With water; In acetone; Reflux;

DOI:10.1021/jo2021949

upstream raw materials:

methyl 3-[[(methoxycarbonyl)imino]amino]but-2-enoate

phenyl isothiocyanate

N-butylamine

Downstream raw materials:

1-butyl-5-(1-hydroxyethylidene)-3-phenyl-2-thioxoimidazolidin-4-one