C₂₃H₁₈Cl₃N₅O₂

Base Information

• Chemical Name: C₂₃H₁₈Cl₃N₅O₂
• CAS No.: 1547120-64-8
• Molecular Formula: C₂₃H₁₈Cl₃N₅O₂
• Molecular Weight: 502.787
• Mol file: 1547120-64-8.mol

Synonyms:C₂₃H₁₈Cl₃N₅O₂

Chemical Property of C₂₃H₁₈Cl₃N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₁₈Cl₃N₅O₂

There total 7 articles about C₂₃H₁₈Cl₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H15ClN4O (1547120-11-5) + N-(3,4-dichlorophenyl)-1-imidazolecarboxamide (33876-96-9) → C23H18Cl3N5O2 (1547120-64-8)

Guidance literature:

In dichloromethane; for 1h;

DOI:10.1016/j.cclet.2013.11.006

Reference yield:

isonicotinic acid ethylester (1570-45-2) → C23H18Cl3N5O2 (1547120-64-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / 5 - 15 °C

2.1: sodium tetrahydroborate / ethanol / 20 °C

3.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 3 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4.2: 2 h

5.1: 5%-palladium/activated carbon; hydrogen / methanol / 0.5 h

6.1: dichloromethane / 1 h

With sodium tetrahydroborate; carbon tetrabromide; sulfuric acid; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; sodium hydride; iron(II) sulfate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2013.11.006

Reference yield:

ethyl 2-methylaminocarbonyl-4-picolinate (332013-42-0) → C23H18Cl3N5O2 (1547120-64-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 20 °C

2.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 2 h

4.1: 5%-palladium/activated carbon; hydrogen / methanol / 0.5 h

5.1: dichloromethane / 1 h

With sodium tetrahydroborate; carbon tetrabromide; 5%-palladium/activated carbon; hydrogen; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2013.11.006

upstream raw materials:

isonicotinic acid ethylester

ethyl 2-methylaminocarbonyl-4-picolinate

4-(hydroxymethyl)-N-methylpyridine-2-carboxamide

4-(bromomethyl)-N-methylpyridine-2-carboxamide