tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate
CAS No.:1374858-95-3
Molecular Formula:C₂₇H₃₅N₅O₄S
Molecular Weight:525.672
Hs Code.:

Synonyms:tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

There total 8 articles about tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1374858-21-5
5-amino-3-cyclohexyl-1,2-thiazole-4-carboxamide

: 1374859-06-9
tert-butyl 4-(4-formyl-3-methoxyphenyl)piperazine-1-carboxylate

: 1374858-95-3
tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

Guidance literature:: In N,N-dimethyl acetamide; at 130 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2012.03.025

Reference yield:

: [chloro(cyclohexyl)methylidene]propanedinitrile

: 1374858-95-3
tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / 0.5 h / 20 °C

2: hydrogen sulfide; triethylamine / benzene

3: dihydrogen peroxide / methanol / 50 °C

4: sulfuric acid / 0.5 h / 80 °C

5: N,N-dimethyl acetamide / 0.5 h / 130 °C

With ammonium hydroxide; sulfuric acid; hydrogen sulfide; dihydrogen peroxide; triethylamine; In methanol; N,N-dimethyl acetamide; benzene;
DOI:10.1016/j.bmcl.2012.03.025

Reference yield:

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1374858-95-3
tert-butyl 4-[4-(3-cyclohexyl-4-oxo-4,5-dihydro[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-3-methoxyphenyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C

1.2: 0 - 20 °C

2.1: trichlorophosphate / Reflux

3.1: ammonium hydroxide / 0.5 h / 20 °C

4.1: hydrogen sulfide; triethylamine / benzene

5.1: dihydrogen peroxide / methanol / 50 °C

6.1: sulfuric acid / 0.5 h / 80 °C

7.1: N,N-dimethyl acetamide / 0.5 h / 130 °C

With ammonium hydroxide; sulfuric acid; hydrogen sulfide; dihydrogen peroxide; sodium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; mineral oil; benzene;
DOI:10.1016/j.bmcl.2012.03.025