2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester
• CAS No.: 158421-65-9
• Molecular Formula: C₂₁H₂₈N₅O₆P
• Molecular Weight: 477.457
• Mol file: 158421-65-9.mol

Synonyms:2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester

Chemical Property of 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Chloromethyl pivalate (18997-19-8) + C15H17N5O4P(1-)*Na(1+) → 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester (158421-65-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 22 ℃; for 2h;

DOI:10.1021/jm00038a015

Reference yield:

Adefovir (106941-25-7) → 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester (158421-65-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 1 h / Heating

2: acetonitrile / 20 h / 22 °C

3: 68 percent / sodium hydride / dimethylsulfoxide / 1 h / 22 °C

4: Et₃N / dimethylformamide / 2 h / 22 °C

With thionyl chloride; sodium hydride; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00038a015

Reference yield:

C8H10Cl2N5O2P (142341-38-6) → 2,2-Dimethyl-propionic acid [2-(6-amino-purin-9-yl)-ethoxymethyl]-benzyloxy-phosphinoyloxymethyl ester (158421-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 20 h / 22 °C

2: 68 percent / sodium hydride / dimethylsulfoxide / 1 h / 22 °C

3: Et₃N / dimethylformamide / 2 h / 22 °C

With sodium hydride; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00038a015

upstream raw materials:

Chloromethyl pivalate

Adefovir

C₈H₁₀Cl₂N₅O₂P

9-<2-(phosphonomethoxy)ethyl>adenine, bis(phenyl ester)

Downstream raw materials:

9-<2-(phosphonomethoxy)ethyl>adenine, mono(pivaloyloxy)methyl ester