Chemical Property of Adefovir
Chemical Property:
- Appearance/Colour:white to off-white powder
- Melting Point:>260 °C
- Boiling Point:632.5 °C at 760 mmHg
- PKA:pKa1 2.0, pKa2 6.8(at 25℃)
- Flash Point:336.3 °C
- PSA：146.19000
- Density:1.88 g/cm3
- LogP:0.14150
- Storage Temp.:-20°C Freezer
- Solubility.:0.1 M NaOH: ≥5mg/mL
- XLogP3:-2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:5
- Exact Mass:273.06269088
- Heavy Atom Count:18
- Complexity:327
- Purity/Quality:
-
99% *data from raw suppliers
Adefovir *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Antiviral Agents
- Canonical SMILES:C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N
- Recent ClinicalTrials:Drug Transporter Interaction Study PHENTRA_2015_KPUK
- Recent NIPH Clinical Trials:Randomized control study for the effectiveness of tenofovir in nucleoside/nucleotide analogue-treated patients with chronic HBV infection
-
Description
Adefovir (Trade name: Preveon, Hepsera) is a prescription drug used
for the treatment of chronic infections of hepatitis B virus. It can
be formulated as the pivoxil prodrug adefovir dipivoxil. However, it
shows no effect against HIV-1. As a orally administrated acyclic
nucleotide analog reverse transcriptase inhibitor, it blocking the
reproduction of HBV through inhibiting the reverse transcriptase in
the body. One of its advantages over another anti-HBV drug,
lamivudine is that it is much harder for the virus to develop
resistance to it.
-
Uses
Used as an antiviral Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.
-
Clinical Use
Treatment of chronic hepatitis B virus infection in patients >12 years
of age
