3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

Base Information

Chemical Name:3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester
CAS No.:936850-80-5
Molecular Formula:C₁₄H₁₂F₃NO₃
Molecular Weight:299.249
Hs Code.:

Synonyms:3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

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Chemical Property of 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

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Technology Process of 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

There total 1 articles about 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53171-39-4
methyl succinamate

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 936850-80-5
3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

Guidance literature:: at 80 ℃; for 4h; Neat (no solvent);

Reference yield: 100.0%

: 936850-80-5
3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

: 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propan-1-ol

Guidance literature:: 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.75h;

With water; sodium sulfate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

: 936850-80-5
3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester

: 1531650-30-2
C₁₅H₁₄F₃NO₃

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.11.002