METHYL SUCCINAMATE

Base Information

• Chemical Name: METHYL SUCCINAMATE
• CAS No.: 53171-39-4
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.131
• Hs Code.: 2924199090
• Mol file: 53171-39-4.mol

Synonyms:Methyl succinamate;

Chemical Property of METHYL SUCCINAMATE

Chemical Property:

• Vapor Pressure: 0.00134mmHg at 25°C
• Melting Point: 89 °C
• Refractive Index: 1.442
• Boiling Point: 297.6 °C at 760 mmHg
• PKA: 15.91±0.40(Predicted)
• Flash Point: 179.5 °C
• PSA: 70.38000
• Density: 1.136 g/cm³
• LogP: 0.57460
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl Succinamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl Succinamate is a useful synthetic intermediate. It is used to synthesize substituted oxazole-benzamide antibacterial inhibitors of FtsZ.

Technology Process of METHYL SUCCINAMATE

There total 8 articles about METHYL SUCCINAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-cyano-propionic acid methyl ester (4107-62-4) → methyl succinamate (53171-39-4)

Guidance literature:

With water; dihydridotetrakis(triphenylphosphine)ruthenium; In 1,2-dimethoxyethane; at 120 ℃; for 24h;

DOI:10.1016/S0040-4020(01)81902-5

Reference yield: 92.0%

Dimethyl succinate (106-65-0) → methyl succinamate (53171-39-4)

Guidance literature:

With ammonia; Candida antarctica lipase SP 435; In 1,4-dioxane; at 30 ℃; for 31h;

DOI:10.1016/0040-4020(94)01043-Y

Reference yield: 91.0%

→ methyl succinamate (53171-39-4)

Guidance literature:

upstream raw materials:

Succinimide

methanol

3-carbamoyl-orthopropionic acid trimethyl ester

3-cyano-propionic acid methyl ester

Downstream raw materials:

Succinimide

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS". Page/Page column 72. . Retrieved 2008/06/13.
• 2、 -. "COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR AN MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE". Page/Page column 72-73. . Retrieved 2008/06/13.