4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

Base Information

• Chemical Name: 4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride
• CAS No.: 1274933-97-9
• Molecular Formula: C₁₁H₁₂N₂O₂*ClH
• Molecular Weight: 240.689
• Mol file: 1274933-97-9.mol

Synonyms:4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

Chemical Property of 4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

Chemical Property:

Purity/Quality:

95-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

There total 1 articles about 4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(2-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (494795-55-0) → 4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (1274933-97-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 0.5h;

Reference yield:

4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (1274933-97-9) + acetyl chloride (75-36-5) → 1-[4-(2-nitro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]ethanone (1274933-98-0)

Guidance literature:

With pyridine; In dichloromethane; for 0.5h;

Reference yield:

4-(2-nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (1274933-97-9) → 1-[4-(2-amino-phenyl)-piperidin-1-yl]-ethanone (1274933-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0.5 h

2: ammonium formate / palladium 10% on activated carbon / water; industrial methylated spirit / 1 h / Reflux

With pyridine; ammonium formate; palladium 10% on activated carbon; In industrial methylated spirit; dichloromethane; water;

upstream raw materials:

tert-butyl 4-(2-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Downstream raw materials:

1-[4-(2-nitro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]ethanone

1-[4-(2-amino-phenyl)-piperidin-1-yl]-ethanone

1-[4-(2-chloro-phenyl)-piperidin-1-yl]-ethanone

4-(2-chloro-phenyl)piperidine hydrochloride