3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride

Base Information

• Chemical Name: 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride
• CAS No.: 1445869-15-7
• Molecular Formula: C₂₀H₂₃N₅O₅*ClH
• Molecular Weight: 449.894
• Mol file: 1445869-15-7.mol

Synonyms:3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride

Chemical Property of 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride

There total 9 articles about 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethyl-5-[1-(4-[(5-nitro-2-furyl)methyl]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (1445869-07-7) → 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride (1445869-15-7)

Guidance literature:

With hydrogenchloride; In methanol; at 0 ℃; for 1h;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride (1445869-15-7)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: hydrazine hydrate / ethanol / 24 h / Reflux

3: pyridine / 2.5 h / 85 °C / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 10 h / 27 °C

5: tin(II) chloride dihdyrate / methanol / 4 h / 65 °C / Reflux

6: acetic acid / methanol / 10 h / 0 °C

7: acetic acid; sodium cyanoborohydride / methanol / 12 h / 0 °C

8: hydrogenchloride / methanol / 1 h / 0 °C

With pyridine; hydrogenchloride; tin(II) chloride dihdyrate; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

isonipecotic acid methyl ester (2971-79-1) → 3-ethyl-5-(1-(4-(1-((5-nitro-2-furyl)methyl)ammonio)phenyl)-4-piperidyl)-2,3-dihydro-1,3,4-oxadiazol-2-one chloride (1445869-15-7)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: hydrazine hydrate / ethanol / 24 h / Reflux

3: pyridine / 2.5 h / 85 °C / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 10 h / 27 °C

5: tin(II) chloride dihdyrate / methanol / 4 h / 65 °C / Reflux

6: acetic acid / methanol / 10 h / 0 °C

7: acetic acid; sodium cyanoborohydride / methanol / 12 h / 0 °C

8: hydrogenchloride / methanol / 1 h / 0 °C

With pyridine; hydrogenchloride; tin(II) chloride dihdyrate; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

3-ethyl-5-[1-(4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

3-ethyl-5-[1-(4-[(5-nitro-2-furyl)methyl]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one

4-Fluoronitrobenzene

isonipecotic acid methyl ester