(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

Base Information

Chemical Name:(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane
CAS No.:1173558-10-5
Molecular Formula:C₄₁H₈₂O₃Si₃
Molecular Weight:707.357
Hs Code.:

(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

Synonyms:(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

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Chemical Property of (1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

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Technology Process of (1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

There total 7 articles about (1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173558-09-2
(S)-9-[(tert-butyldimethylsilyl)oxy]-3,3,5,9-tetramethyldecanal

: 213250-64-7
[2-[(3'R,5'R)-3',5'-bis[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: (1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(Z)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

: 1173558-10-5
(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

Guidance literature:: [2-[(3'R,5'R)-3',5'-bis[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; With phenyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.333333h;

(S)-9-[(tert-butyldimethylsilyl)oxy]-3,3,5,9-tetramethyldecanal; In tetrahydrofuran; cyclohexane; at -78 - 6 ℃; for 19h;

Reference yield:

: 1173557-99-7
(2RS,4S)-8-[(tert-butyldimethylsilyl)oxy]-2-[2'-[(tert-butyldimethylsilyl)oxy]ethyl]-2,4,8-trimethylnonanoic acid methyl ester

: (1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(Z)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

: 1173558-10-5
(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C

2.1: tetrahydrofuran / 22 h / 20 - 75 °C

3.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 20 h / 20 - 120 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / 20 °C / Molecular sieve

6.1: phenyllithium / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C / Inert atmosphere

6.2: 19 h / -78 - 6 °C

With tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; diisobutylaluminium hydride; phenyllithium; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; cyclohexane; toluene; 6.2: Wittig-Horner coupling;
DOI:10.1016/j.bmc.2011.09.048

Reference yield:

: 1173558-02-5
(2RS,4S)-8-[(tert-butyldimethylsilyl)oxy]-2-[2'-[(tert-butyldimethylsilyl)oxy]ethyl]-2,4,8-trimethylnonan-1-ol

: (1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(Z)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

: 1173558-10-5
(1R,3R)-1,3-bis-[(tert-butyldimethylsilyl)oxy]-5-[(E)-(S)-11'-[(tert-butyldimethylsilyl)oxy]-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-methylene-cyclohexane

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 22 h / 20 - 75 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 20 h / 20 - 120 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / 20 °C / Molecular sieve

5.1: phenyllithium / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C / Inert atmosphere

5.2: 19 h / -78 - 6 °C

With tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; phenyllithium; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; cyclohexane; toluene; 5.2: Wittig-Horner coupling;
DOI:10.1016/j.bmc.2011.09.048