({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

Base Information

Chemical Name:({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester
CAS No.:185670-59-1
Molecular Formula:C₂₁H₂₇N₄O₉P
Molecular Weight:510.441
Hs Code.:

({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

Synonyms:({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

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Chemical Property of ({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

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Technology Process of ({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

There total 5 articles about ({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 185670-58-0
({{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

: 185670-59-1
({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: With acetic acid; for 4h; Ambient temperature;

Reference yield:

: 20924-05-4
thymidyl acetic acid

: 185670-59-1
({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / HOBT, N-ethylmorpholine, diisopropylcarbodiimide / dimethylformamide / 16 h / Ambient temperature

2: 90 percent / 0.1 M DBU / pyridine / 4 h

3: 95 percent / 3-nitro-1-(p-toluenesulfonyl)-1H-1,2,4-triazole / pyridine

4: 80 percent / 80percent AcOH / 4 h / Ambient temperature

With N-ethylmorpholine;; benzotriazol-1-ol; 1-(toluene-p-sulphonyl)-3-nitro-1,2,4-triazole; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropyl-carbodiimide; In pyridine; N,N-dimethyl-formamide;

Reference yield:

: 183057-48-9
({2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethylamino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

: 185670-59-1
({(2-Hydroxy-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid allyl ester 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / HOBT, N-ethylmorpholine, diisopropylcarbodiimide / dimethylformamide / 16 h / Ambient temperature

2: 90 percent / 0.1 M DBU / pyridine / 4 h

3: 95 percent / 3-nitro-1-(p-toluenesulfonyl)-1H-1,2,4-triazole / pyridine

4: 80 percent / 80percent AcOH / 4 h / Ambient temperature

With N-ethylmorpholine;; benzotriazol-1-ol; 1-(toluene-p-sulphonyl)-3-nitro-1,2,4-triazole; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropyl-carbodiimide; In pyridine; N,N-dimethyl-formamide;