2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

Base Information

Chemical Name:2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine
CAS No.:263008-97-5
Molecular Formula:C₂₅H₃₂ClN₃O₁₀
Molecular Weight:569.996
Hs Code.:

Synonyms:2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

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Chemical Property of 2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

Chemical Property:

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Technology Process of 2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

There total 6 articles about 2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methoxy-acetic acid 2-{1-(2-chloro-phenyl)-4-[(2R,3R,3aR,9aR)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-piperidin-4-yloxy}-ethyl ester

: 263008-97-5
2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

Guidance literature:: With tetraethylammonium fluoride; In acetonitrile; at 20 ℃; for 0.75h;
DOI:10.1039/a908149f

Reference yield:

: 3592-25-4
1,5-dichloropentan-3-one

: 263008-97-5
2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / TsOH*H₂O / light petroleum / 3.5 h / Heating

2: CF₃SO₃SiMe₃; DIPEA / CH₂Cl₂ / 0.5 h / 0 °C

3: pyridine / 6 h / 20 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

5: Et₄NF / acetonitrile / 0.75 h / 20 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; tetraethylammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile; Petroleum ether; 1: Alkylation / 2: Ring cleavage / 3: Acylation / 4: Addition / 5: Desilylation;
DOI:10.1039/a908149f

Reference yield:

: 95-51-2
o-chloroaniline

: 263008-97-5
2'-O-{1-(2-Chlorophenyl)-4-[2-(methoxyacetoxy)ethoxy]-piperidin-4-yl}uridine

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / TsOH*H₂O / light petroleum / 3.5 h / Heating

2: CF₃SO₃SiMe₃; DIPEA / CH₂Cl₂ / 0.5 h / 0 °C

3: pyridine / 6 h / 20 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

5: Et₄NF / acetonitrile / 0.75 h / 20 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; tetraethylammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile; Petroleum ether; 1: Alkylation / 2: Ring cleavage / 3: Acylation / 4: Addition / 5: Desilylation;
DOI:10.1039/a908149f