(4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

Base Information

Chemical Name:(4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane
CAS No.:780772-20-5
Molecular Formula:C₂₁H₂₁F₁₃O₃
Molecular Weight:568.375
Hs Code.:

Synonyms:(4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

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Chemical Property of (4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

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Technology Process of (4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

There total 3 articles about (4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 780773-39-9
(2R,3S)-2-methyl-1,3-bis(trimethylsilanyloxy)butane

: 4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)benzaldehyde

: 780772-20-5
(4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 12h;
DOI:10.1021/jo051526a

Reference yield:

: 27372-03-8,51898-35-2,51898-36-3,63647-69-8,78088-27-4,78088-28-5,86853-34-1,92282-67-2,86853-33-0
ethyl anti-(2R,3R)-2-methyl-3-hydroxybutanoate

: 780772-20-5
(4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / lithium aluminum hydride / diethyl ether / 3 h / 20 °C

2: 84 percent / triethylamine / tetrahydrofuran / 16 h / 20 °C

3: 81 percent / trimethylsilyl triflate / CH₂Cl₂ / 12 h / -78 °C

With lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 3: Noyori ketalization;
DOI:10.1021/jo051526a

Reference yield:

: 90026-43-0
(2R,3S)-2-methylbutane-1,3-diol

: 780772-20-5
(4R,5S)-4,5-dimethyl-2-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)phenyl]-[1,3]dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / triethylamine / tetrahydrofuran / 16 h / 20 °C

2: 81 percent / trimethylsilyl triflate / CH₂Cl₂ / 12 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; dichloromethane; 2: Noyori ketalization;
DOI:10.1021/jo051526a