N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

Base Information

Chemical Name:N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide
CAS No.:1575517-24-6
Molecular Formula:C₂₆H₃₆ClNO₃Si
Molecular Weight:474.115
Hs Code.:

Synonyms:N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

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Technology Process of N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

There total 1 articles about N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: C₂₀H₂₂ClNO₃

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1575517-24-6
N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2014.02.033

Reference yield:

: 1575517-24-6
N-((2S,3R,E)-3-((tert-butyldimethylsilyl)oxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

: 1575517-26-8
(4S,5S,6S)-5-((tert-butyldimethylsilyl)oxy)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazine

: 1575517-60-0
(4S,5S,6R)-5-((tert-butyldimethylsilyl)oxy)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 12h; Overall yield = 72 %; Overall yield = 246 mg; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2014.02.033