N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester
• CAS No.: 1026701-52-9
• Molecular Formula: C₂₇H₄₀N₂O₆S
• Molecular Weight: 520.69
• Mol file: 1026701-52-9.mol

Synonyms:N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

Chemical Property of N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

There total 3 articles about N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-[(1S,2R)-2-hydroxy-3-[((2S)-2-methylbutyl)amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester (1026701-65-4) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester (1026701-52-9)

Guidance literature:

With sodium carbonate; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja076558p

Reference yield:

(S)-2-methylbutylamine (34985-37-0) → N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester (1026701-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: sodium carbonate / dichloromethane; water / 6 h / 0 - 20 °C

With sodium carbonate; In ethanol; dichloromethane; water;

DOI:10.1021/jm300238h

Reference yield:

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) → N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester (1026701-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: sodium carbonate / dichloromethane; water / 6 h / 0 - 20 °C

With sodium carbonate; In ethanol; dichloromethane; water;

DOI:10.1021/jm300238h

upstream raw materials:

N-[(1S,2R)-2-hydroxy-3-[((2S)-2-methylbutyl)amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

4-methoxy-phenyl-sulphonyl chloride

(S)-2-methylbutylamine

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

Downstream raw materials:

C₂₂H₃₂N₂O₄S

C₂₉H₄₀N₂O₈S

2-(2-oxoimidazolidin-1-yl)ethyl ((2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-yl)carbamate

(R)-methyl 3-((((2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-yl)carbamoyl)oxy)-2-methylpropanoate