3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

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Chemical Name:3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene
CAS No.:1444124-75-7
Molecular Formula:C₃₁H₄₀O₂Si
Molecular Weight:472.743
Hs Code.:

Synonyms:3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

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Chemical Property of 3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

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Technology Process of 3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

There total 3 articles about 3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 17156-64-8
(dimethylphenylsilyl)acetylene

: 4290-66-8
3-ethoxy-16-methylene-19-norandrosta-3,5-dien-17-one

: 1444124-75-7
3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

Guidance literature:: (dimethylphenylsilyl)acetylene; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

3-ethoxy-16-methylene-19-norandrosta-3,5-dien-17-one; In tetrahydrofuran; for 0.005h; Inert atmosphere;

Reference yield:

: 734-32-7
estra-4-ene-3,17-dione

: 1444124-75-7
3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / Acidic conditions

2.1: oxalic acid diethyl ester / 0.1 h

2.2: 0.2 h / 0 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.01 h / Inert atmosphere

With oxalic acid diethyl ester; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 2863-88-9
3-ethoxy-19-nor-3,5-androstadiene-17-one

: 1444124-75-7
3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalic acid diethyl ester / 0.1 h

1.2: 0.2 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.01 h / Inert atmosphere

With oxalic acid diethyl ester; lithium hexamethyldisilazane; In tetrahydrofuran;