methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate

Base Information

• Chemical Name: methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate
• CAS No.: 641638-69-9
• Molecular Formula: C₁₉H₂₄N₂O₄S
• Molecular Weight: 376.477
• Mol file: 641638-69-9.mol

Synonyms:methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate

Chemical Property of methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate

There total 5 articles about methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

methyl 1-cycloheptyl-5-(4-methylthiophenyl)pyrazol-3-carboxylate (641638-67-7) → methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate (641638-69-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm030276s

Reference yield:

4-(Methylthio)acetophenone (1778-09-2) → methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate (641638-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2: 100 percent / CF₃CO₂H / methanol / 70 °C

3: 54 percent / m-CPBA / CH₂Cl₂ / 1 h / 20 °C

With sodium methylate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; toluene;

DOI:10.1021/jm030276s

Reference yield:

cycloheptylhydrazine (17630-34-1) → methyl 1-cycloheptyl-5-(4-(methylsulfonyl)phenyl)pyrazol-3-carboxylate (641638-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CF₃CO₂H / methanol / 70 °C

2: 54 percent / m-CPBA / CH₂Cl₂ / 1 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/jm030276s

upstream raw materials:

methyl 1-cycloheptyl-5-(4-methylthiophenyl)pyrazol-3-carboxylate

4-(Methylthio)acetophenone

cycloheptylhydrazine

N'-cycloheptyl-hydrazinecarboxylic acid tert-butyl ester

Downstream raw materials:

[1-cycloheptyl-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-methanol