3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

Base Information

Chemical Name:3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide
CAS No.:1428443-71-3
Molecular Formula:C₂₁H₁₇N₅O₂
Molecular Weight:371.398
Hs Code.:

Synonyms:3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

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Chemical Property of 3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

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Technology Process of 3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

There total 6 articles about 3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 5424-01-1
3-aminopyrazinoic acid

: 1428443-61-1
2-azido-1-(2-phenyl-1H-indol-3-yl)-ethanone

: 1428443-62-2
2-amino-1-(2-phenyl-1H-indol-3-yl)-ethanone

: 1428443-71-3
3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

Guidance literature:: 2-azido-1-(2-phenyl-1H-indol-3-yl)-ethanone; With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; for 1.33333h;

3-aminopyrazinoic acid; 2-amino-1-(2-phenyl-1H-indol-3-yl)-ethanone; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c2ra21902f

Reference yield: 47.0%

: 5424-01-1
3-aminopyrazinoic acid

: 1428443-62-2
2-amino-1-(2-phenyl-1H-indol-3-yl)-ethanone

: 1428443-71-3
3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 22h; Inert atmosphere;
DOI:10.1039/c2ra21902f

Reference yield:

: 412022-79-8
2-chloro-1-(2-phenyl-1H-indol-3-yl)ethanone

: 1428443-71-3
3-amino-N-(2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / dimethyl sulfoxide / 2.25 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1.75 h

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1.33 h

3.2: 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1039/c2ra21902f