(3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

Base Information

Chemical Name:(3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride
CAS No.:1433397-69-3
Molecular Formula:C₁₈H₁₈ClFN₂O₂*ClH
Molecular Weight:385.265
Hs Code.:

Synonyms:(3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

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Chemical Property of (3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

Chemical Property:

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Technology Process of (3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

There total 5 articles about (3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433408-72-0
(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

: 1433397-69-3
(3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

Guidance literature:: (3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester; With water; lithium hydroxide; In methanol; at 20 ℃;

With ammonium chloride; diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield:

: 1433409-07-4
(6-chloro-2-fluoro-3-methylphenyl)phenylmethanone

: 1433397-69-3
(3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

3.1: triethylamine; acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 48 h

3.2: 0.17 h

4.1: water; lithium hydroxide / methanol / 20 °C

4.2: 3 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; triethylamine; lithium hydroxide; In methanol; tetrachloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 1433402-50-6
3-benzoyl-4-chloro-2-fluorobenzaldehyde

: 1433397-69-3
(3S)-3-{[(3-benzoyl-4-chloro-2-fluorophenyl)methyl]amino}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 48 h

1.2: 0.17 h

2.1: water; lithium hydroxide / methanol / 20 °C

2.2: 3 h / 20 °C

With water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hydroxide; In methanol; 1,2-dichloro-ethane;