(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

Base Information

Chemical Name:(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester
CAS No.:1433408-72-0
Molecular Formula:C₂₀H₂₁ClFNO₃
Molecular Weight:377.843
Hs Code.:

Synonyms:(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

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Chemical Property of (3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

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Technology Process of (3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

There total 5 articles about (3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433402-50-6
3-benzoyl-4-chloro-2-fluorobenzaldehyde

: 146293-15-4,102014-64-2
[(1S)-3-ethoxy-1-methyl-3-oxopropyl]ammonium chloride

: 1433408-72-0
(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

Guidance literature:: 3-benzoyl-4-chloro-2-fluorobenzaldehyde; [(1S)-3-ethoxy-1-methyl-3-oxopropyl]ammonium chloride; With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In 1,2-dichloro-ethane; for 48h;

With sodium hydrogencarbonate; In 1,2-dichloro-ethane; for 0.166667h;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1433408-72-0
(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

1.2: 0.75 h

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

4.1: triethylamine; acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 48 h

4.2: 0.17 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tributylphosphine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; triethylamine; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 1433409-07-4
(6-chloro-2-fluoro-3-methylphenyl)phenylmethanone

: 1433408-72-0
(3S)-3-(3-benzoyl-4-chloro-2-fluorobenzylamino)butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

3.1: triethylamine; acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 48 h

3.2: 0.17 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; triethylamine; In tetrachloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;