1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

Chemical Name:1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate
CAS No.:1246248-48-5
Molecular Formula:C₄₆H₆₆N₆O₆
Molecular Weight:799.067
Hs Code.:

1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Synonyms:1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

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Chemical Property of 1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

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Technology Process of 1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

There total 5 articles about 1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246248-47-4
tert-butyl (3-(isopropylamino)propyl)(methyl)carbamate

: 1246247-06-2
4-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)benzoic acid

: 1246248-48-5
1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: 4-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)benzoic acid; With pivaloyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

tert-butyl (3-(isopropylamino)propyl)(methyl)carbamate; In dichloromethane; at 80 ℃; for 72h;

Reference yield:

: 98642-44-5
tert-butyl (3-hydroxypropyl)methylcarbamate

: 1246248-48-5
1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.17 h / Cooling with ice

1.2: 20 °C

2.1: triethylamine; pivaloyl chloride / dichloromethane / 0.17 h / 20 °C

2.2: 72 h / 80 °C

With pivaloyl chloride; methanesulfonyl chloride; triethylamine; In dichloromethane;

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 1246248-48-5
1-(2-{[6-({4-[{3-[(tert-Butoxycarbonyl)(methyl)amino]propyl}(isopropyl)carbamoyl] phenyl}amino)hexanoyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 50 °C

1.2: 96 h / 50 °C

2.1: sodium hydroxide; water / ethanol / 3.5 h / 20 °C

2.3: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

4.1: triethylamine; pivaloyl chloride / dichloromethane / 0.17 h / 20 °C

4.2: 72 h / 80 °C

With hydrogenchloride; water; pivaloyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;