Technology Process of 4-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[3,4,5-cd]indole hydrochloride
There total 5 articles about 4-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[3,4,5-cd]indole hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
formaldehyd; 1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[3,4,5-cd]indole hydrochloride;
With
sodium tris(acetoxy)borohydride; acetic acid;
In
tetrahydrofuran; water;
at 70 ℃;
for 0.0833333h;
Microwave irradiation;
With
hydrogenchloride;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
1.2: 1.05 h / 0 - 20 °C
2.1: ammonium acetate / 20 °C / Heating / reflux
3.1: sodium tetrahydroborate / nickel boride / tetrahydrofuran; methanol / 3.58 h / 0 - 20 °C
4.1: water / 20 h / 20 °C
5.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran; water / 0.08 h / 70 °C / Microwave irradiation
With
sodium tetrahydroborate; ammonium acetate; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid;
nickel boride;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium acetate / 20 °C / Heating / reflux
2: sodium tetrahydroborate / nickel boride / tetrahydrofuran; methanol / 3.58 h / 0 - 20 °C
3: water / 20 h / 20 °C
4: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran; water / 0.08 h / 70 °C / Microwave irradiation
With
sodium tetrahydroborate; ammonium acetate; sodium tris(acetoxy)borohydride; acetic acid;
nickel boride;
In
tetrahydrofuran; methanol; water;
