6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

Base Information

Chemical Name:6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol
CAS No.:81457-11-6
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

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Chemical Property of 6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

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Technology Process of 6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

There total 11 articles about 6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 81457-10-5
3-(allyloxy)-2,6-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>toluene

: 81457-12-7
2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

: 81457-11-6
6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

Guidance literature:: In various solvent(s); for 2.5h; Heating;
DOI:10.1021/jo00133a034

Reference yield:

: 43041-12-9,52183-82-1,2577-48-2
methyl pyrrolidine-2-carboxylate

: 81457-11-6
6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min

2: 1.) 1 M aq. Na₂S₂O₄ (pH 7.0), 2.) Na₂S₂O₄ / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min

3: K₂CO₃ / various solvent(s) / 1.5 h / Heating

4: various solvent(s) / 41 h

5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature

6: 96 percent / H₂ / 5percent Pd/C / methanol / 42 h / 2585.7 Torr

7: 100 percent / K₂CO₃ / dimethylformamide / 10.5 h

8: 61 percent / various solvent(s) / 2.5 h / Heating

With sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034

Reference yield:

: 2207-57-0
2-methoxy-3-methyl-1,4-benzoquinone

: 81457-11-6
6-allyl-2,4-dimethoxy-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-3-methylphenol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min

2: 1.) 1 M aq. Na₂S₂O₄ (pH 7.0), 2.) Na₂S₂O₄ / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min

3: K₂CO₃ / various solvent(s) / 1.5 h / Heating

4: various solvent(s) / 41 h

5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature

6: 96 percent / H₂ / 5percent Pd/C / methanol / 42 h / 2585.7 Torr

7: 100 percent / K₂CO₃ / dimethylformamide / 10.5 h

8: 61 percent / various solvent(s) / 2.5 h / Heating

With sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034